HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2-Chlorophenyl)piperazine → 1-[(6-Fluoro-2-methoxyquinoxalin-3-yl)aminocarbonyl]-4-(2-chlorophenyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2-Chlorophenyl)piperazine | HCID 415628 | — |
| Reactant | Ethyl N-(6-fluoro-2-methoxyquinoxalin-3-yl)carbamate | HCID 66917965 | — |
| Product | 1-[(6-Fluoro-2-methoxyquinoxalin-3-yl)aminocarbonyl]-4-(2-chlorophenyl)piperazine | HCID 11704375 | 87% |
Reaction Steps
Ethyl N-(6-fluoro-2-methoxyquinoxalin-3-yl)carbamate and 1-(2-chlorophenyl)piperazine were reacted by the same way with the example 1 to obtain the titled compound (yield, 87%). 1H NMR (200 MHz, CDCl3): δ 3.14 (s, 4H), 3.79 (s, 3H), 4.13 (s, 4H), 6.97-7.05 (m, 2H), 7.22-7.28 (m, 2H), 7.33-7.40 (m, 2H), 7.46-7.51 (d, J=10.2 Hz, 1H), 7.66-7.73 (m, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08598173B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-49726f487ad0473f95a399aec355e94f |
| Source note | uspto-grants-2013_12 |