N-(2-Cyanophenyl)piperazine → HCID 11647139, compound

HRID 1907459Notes

Reaction equation

HRID 1907459 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([O:12][CH3:13])[C:6]([NH:14][C:15](=[O:19])OCC)=[N:5]2.[C:20]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[N:28]1[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1)#[N:21]>>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([O:12][CH3:13])[C:6]([NH:14][C:15]([N:31]1[CH2:30][CH2:29][N:28]([C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=3[C:20]#[N:21])[CH2:33][CH2:32]1)=[O:19])=[N:5]2

Participants

3

Reactant 2

HCID 2735875N-(2-Cyanophenyl)piperazineHCID 66917965Ethyl N-(6-fluoro-2-methoxyquinoxalin-3-yl)carbamate

Product 1

HCID 11647139HCID 11647139, compoundYield 85%

Procedure

Ethyl N-(6-fluoro-2-methoxyquinoxalin-3-yl)carbamate and 1-(2-cyanophenyl)piperazine were reacted by the same way with the example 1 to obtain the titled compound (yield, 85%). 1H NMR (200 MHz, CDCl3): δ 3.31 (s, 4H), 3.73-3.85 (m, 3H), 4.06-4.16 (m, 4H), 7.03-7.11 (m, 3H), 7.20-7.34 (m, 1H), 7.50-7.62 (m, 3H), 7.67-7.74 (m, 1H).

Sources & evidence

ORD record
ord-20da56de1b634999bc14480b944401fd
Source dataset
uspto-grants-2013_12
Patent number
US08598173B2

Reaction notes

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