Piperazin-4-ylacetophenone → HCID 11524654, compound

HRID 1907460Notes

Reaction equation

HRID 1907460 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([O:12][CH3:13])[C:6]([NH:14][C:15](=[O:19])OCC)=[N:5]2.[C:20]([C:23]1[CH:28]=[CH:27][C:26]([N:29]2[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]2)=[CH:25][CH:24]=1)(=[O:22])[CH3:21]>>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([O:12][CH3:13])[C:6]([NH:14][C:15]([N:32]1[CH2:31][CH2:30][N:29]([C:26]3[CH:25]=[CH:24][C:23]([C:20](=[O:22])[CH3:21])=[CH:28][CH:27]=3)[CH2:34][CH2:33]1)=[O:19])=[N:5]2

Participants

3

Reactant 2

HCID 97269Piperazin-4-ylacetophenoneHCID 66917965Ethyl N-(6-fluoro-2-methoxyquinoxalin-3-yl)carbamate

Product 1

HCID 11524654HCID 11524654, compoundYield 90%

Procedure

Ethyl N-(6-fluoro-2-methoxyquinoxalin-3-yl)carbamate and 1-(4-acetylphenyl)piperazine were reacted by the same way with the example 1 to obtain the titled compound (yield, 90%). 1H NMR (200 MHz, CDCl3): δ 2.54 (s, 3H), 3.42-3.48 (m, 4H), 3.79 (s, 3H), 4.14 (s, 4H), 6.89 (d, J=9.0 Hz, 2H), 7.10-7.50 (m, 3H), 7.69-7.80 (m, 1H), 7.91 (d, J=7.8 Hz, 2H).

Sources & evidence

ORD record
ord-db7d6680bbcf49379d2754aba03976e5
Source dataset
uspto-grants-2013_12
Patent number
US08598173B2

Reaction notes

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