2-Mepp → HCID 66918077, compound

HRID 1907471Notes

Reaction equation

HRID 1907471 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([O:12][CH3:13])[C:6]([NH:14][C:15](=[O:19])OCC)=[N:5]2.[CH3:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[N:27]1[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([O:12][CH3:13])[C:6]([NH:14][C:15]([N:30]1[CH2:31][CH2:32][N:27]([C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=3[CH3:20])[CH2:28][CH2:29]1)=[O:19])=[N:5]2

Participants

3

Reactant 2

HCID 919652-MeppHCID 66918182Ethyl N-(6-chloro-2-methoxyquinoxalin-3-yl)carbamate

Product 1

HCID 66918077HCID 66918077, compoundYield 80%

Procedure

Ethyl N-(6-chloro-2-methoxyquinoxalin-3-yl)carbamate and 1-(2-methylphenyl)piperazine were reacted by the same way with the example 22 to obtain the titled compound (yield, 80%). 1H NMR (300 MHz, CDCl3): δ 2.35 (s, 3H), 2.95-3.02 (m, 4H), 3.74-3.77 (m, 3H), 4.08-4.14 (m, 4H), 7.01-7.57 (m, 7H), 7.64-7.85 (m, 1H).

Sources & evidence

ORD record
ord-0d99eca7a97b4beda839970f1cc6ef89
Source dataset
uspto-grants-2013_12
Patent number
US08598173B2

Reaction notes

Loading…