1-(3-Chlorophenyl)piperazine → HCID 66918074, compound

HRID 1907500Notes

Reaction equation

HRID 1907500 reaction equation
[CH3:1][O:2][C:3]1[C:12]([NH:13][C:14](=[O:18])OCC)=[N:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH3:19])[CH:9]=2)[N:4]=1.[Cl:20][C:21]1[CH:22]=[C:23]([N:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)[CH:24]=[CH:25][CH:26]=1>>[CH3:1][O:2][C:3]1[C:12]([NH:13][C:14]([N:30]2[CH2:29][CH2:28][N:27]([C:23]3[CH:24]=[CH:25][CH:26]=[C:21]([Cl:20])[CH:22]=3)[CH2:32][CH2:31]2)=[O:18])=[N:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH3:19])[CH:9]=2)[N:4]=1

Participants

3

Reactant 2

HCID 13551-(3-Chlorophenyl)piperazineHCID 66917958Ethyl N-(2-methoxy-6-methylquinoxalin-3-yl)carbamate

Product 1

HCID 66918074HCID 66918074, compoundYield 72%

Procedure

Ethyl N-(2-methoxy-6-methylquinoxalin-3-yl)carbamate and 1-(3-chlorophenyl)piperazine were reacted by the same way with the example 43 to obtain the titled compound (yield, 72%). 1H NMR (300 MHz, CDCl3): δ 2.45 (s, 3H), 3.26 (s, 4H), 3.77 (s, 3H), 4.08-4.18 (m, 4H), 6.78-6.90 (m, 3H), 7.15-7.38 (m, 3H), 7.56-7.64 (m, 2H).

Sources & evidence

ORD record
ord-b8b7bffb795a46789a39fb4ad84f936a
Source dataset
uspto-grants-2013_12
Patent number
US08598173B2

Reaction notes

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