HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-Chlorophenyl)piperazine → 1-[(2-Methoxy-6-methylquinoxalin-3-yl)aminocarbonyl]-4-(4-chlorophenyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-Chlorophenyl)piperazine | HCID 97478 | — |
| Reactant | Ethyl N-(2-methoxy-6-methylquinoxalin-3-yl)carbamate | HCID 66917958 | — |
| Product | 1-[(2-Methoxy-6-methylquinoxalin-3-yl)aminocarbonyl]-4-(4-chlorophenyl)piperazine | HCID 66918227 | 78% |
Reaction Steps
Ethyl N-(2-methoxy-6-methylquinoxalin-3-yl)carbamate and 1-(4-chlorophenyl)piperazine were reacted by the same way with the example 43 to obtain the titled compound (yield, 78%). 1H NMR (300 MHz, CDCl3): δ 2.44-2.47 (m, 3H), 3.19-3.26 (m, 4H), 3.78 (s, 3H), 4.12 (s, 4H), 6.87 (d, J=8.9 Hz, 2H), 7.01-7.11 (m, 1H), 7.22-7.26 (m, 3H), 7.52-7.61 (m, 2H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08598173B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-1da9f8a4077641ad93c0afd05d97c0c3 |
| Source note | uspto-grants-2013_12 |