Piperazin-4-ylacetophenone → HCID 66918096, compound

HRID 1907503Notes

Reaction equation

HRID 1907503 reaction equation
[CH3:1][O:2][C:3]1[C:12]([NH:13][C:14](=[O:18])OCC)=[N:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH3:19])[CH:9]=2)[N:4]=1.[C:20]([C:23]1[CH:28]=[CH:27][C:26]([N:29]2[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]2)=[CH:25][CH:24]=1)(=[O:22])[CH3:21]>>[CH3:1][O:2][C:3]1[C:12]([NH:13][C:14]([N:32]2[CH2:31][CH2:30][N:29]([C:26]3[CH:25]=[CH:24][C:23]([C:20](=[O:22])[CH3:21])=[CH:28][CH:27]=3)[CH2:34][CH2:33]2)=[O:18])=[N:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH3:19])[CH:9]=2)[N:4]=1

Participants

3

Reactant 2

HCID 97269Piperazin-4-ylacetophenoneHCID 66917958Ethyl N-(2-methoxy-6-methylquinoxalin-3-yl)carbamate

Product 1

HCID 66918096HCID 66918096, compoundYield 87%

Procedure

Ethyl N-(2-methoxy-6-methylquinoxalin-3-yl)carbamate and 1-(4-acetylphenyl)piperazine were reacted by the same way with the example 43 to obtain the titled compound (yield, 87%). 1H NMR (300 MHz, CDCl3): δ 2.45-2.53 (m, 6H), 3.47 (s, 4H), 3.81 (s, 3H), 3.87-4.13 (m, 4H), 6.88 (d, J=8.7 Hz, 2H), 7.22-7.36 (m, 2H), 7.56-7.76 (m, 2H), 7.90 (d, J=8.7 Hz, 2H).

Sources & evidence

ORD record
ord-9caf11c45cfc4ec991214c7ab5ac1ae6
Source dataset
uspto-grants-2013_12
Patent number
US08598173B2

Reaction notes

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