1-(3,4,5-Trimethoxyphenyl)piperazine → 1-[(2,6-Dimethoxyquinoxalin-3-yl)aminocarbonyl]-4-(3,4,5-trimethoxyphenyl)piperazine

HRID 1907514Notes

Reaction equation

HRID 1907514 reaction equation
[CH3:1][O:2][C:3]1[C:12]([NH:13][C:14](=[O:18])OCC)=[N:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([O:19][CH3:20])[CH:9]=2)[N:4]=1.[CH3:21][O:22][C:23]1[CH:24]=[C:25]([N:33]2[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]2)[CH:26]=[C:27]([O:31][CH3:32])[C:28]=1[O:29][CH3:30]>>[CH3:1][O:2][C:3]1[C:12]([NH:13][C:14]([N:36]2[CH2:35][CH2:34][N:33]([C:25]3[CH:24]=[C:23]([O:22][CH3:21])[C:28]([O:29][CH3:30])=[C:27]([O:31][CH3:32])[CH:26]=3)[CH2:38][CH2:37]2)=[O:18])=[N:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([O:19][CH3:20])[CH:9]=2)[N:4]=1

Participants

3

Reactant 2

HCID 38387651-(3,4,5-Trimethoxyphenyl)piperazineHCID 66918080Ethyl N-(2,6-dimethoxyquinoxalin-3-yl)carbamate

Product 1

HCID 669181841-[(2,6-Dimethoxyquinoxalin-3-yl)aminocarbonyl]-4-(3,4,5-trimethoxyphenyl)piperazineYield 97%

Procedure

Ethyl N-(2,6-dimethoxyquinoxalin-3-yl)carbamate and 1-(3,4,5-trimethoxyphenyl)piperazine were reacted by the same way with the example 64 to obtain the titled compound (yield, 97%). 1H NMR (300 MHz, CDCl3): δ 3.55-3.87 (m, 10H), 4.12 (s, 4H), 6.67 (d, J=8.4 Hz, 1H), 7.14 (d, J=9.0 Hz, 1H), 7.25 (s, 1H), 7.34 (s, 1H), 7.51 (t, J=7.2 Hz, 1H), 7.64 (d, J=9.0 Hz, 1H), 8.21 (d, J=3.6 Hz, 1H).

Sources & evidence

ORD record
ord-0a278776e07a4ae8b81c79325a0d4e3b
Source dataset
uspto-grants-2013_12
Patent number
US08598173B2

Reaction notes

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