1-(m-Tolyl)piperazine → 1-[(2,6-Dimethoxyquinoxalin-3-yl)aminocarbonyl]-4-(3-methylphenyl)piperazine

HRID 1907516Notes

Reaction equation

HRID 1907516 reaction equation
[CH3:1][O:2][C:3]1[C:12]([NH:13][C:14](=[O:18])OCC)=[N:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([O:19][CH3:20])[CH:9]=2)[N:4]=1.[CH3:21][C:22]1[CH:23]=[C:24]([N:28]2[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)[CH:25]=[CH:26][CH:27]=1>>[CH3:1][O:2][C:3]1[C:12]([NH:13][C:14]([N:31]2[CH2:32][CH2:33][N:28]([C:24]3[CH:25]=[CH:26][CH:27]=[C:22]([CH3:21])[CH:23]=3)[CH2:29][CH2:30]2)=[O:18])=[N:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([O:19][CH3:20])[CH:9]=2)[N:4]=1

Participants

3

Reactant 2

HCID 831111-(m-Tolyl)piperazineHCID 66918080Ethyl N-(2,6-dimethoxyquinoxalin-3-yl)carbamate

Product 1

HCID 669179891-[(2,6-Dimethoxyquinoxalin-3-yl)aminocarbonyl]-4-(3-methylphenyl)piperazineYield 95%

Procedure

Ethyl N-(2,6-dimethoxyquinoxalin-3-yl)carbamate and 1-(3-methylphenyl)piperazine were reacted by the same way with the example 64 to obtain the titled compound (yield, 95%). 1H NMR (300 MHz, CDCl3): δ 2.33 (s, 3H), 3.26 (s, 4H), 3.72-3.89 (m, 6H), 4.09-4.18 (m, 4H), 6.72-6.78 (m, 4H), 7.03-7.37 (m, 3H), 7.57-7.65 (m, 1H).

Sources & evidence

ORD record
ord-532ef29a48384a37a6b904310fb33795
Source dataset
uspto-grants-2013_12
Patent number
US08598173B2

Reaction notes

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