1-(2-Methoxyphenyl)piperazine → HCID 69240828, compound

HRID 1907533Notes

Reaction equation

HRID 1907533 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([NH:12][C:13](=[O:17])OCC)[C:6]([O:18][CH3:19])=[N:5]2.[CH3:20][O:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[N:28]1[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1>>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([NH:12][C:13]([N:31]1[CH2:30][CH2:29][N:28]([C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=3[O:21][CH3:20])[CH2:33][CH2:32]1)=[O:17])[C:6]([O:18][CH3:19])=[N:5]2

Participants

3

Reactant 2

HCID 13461-(2-Methoxyphenyl)piperazineHCID 69243333ethyl N-(6-fluoro-3-methoxyquinoxalin-2-yl)carbamate

Product 1

HCID 69240828HCID 69240828, compoundYield 82%

Procedure

Ethyl N-(6-fluoro-3-methoxyquinoxalin-2-yl)carbamate and 1-(2-methoxyphenyl) piperazine were reacted by the same way with the example 85 to obtain the titled compound (yield, 82%). 1H NMR (200 MHz, CDCl3): δ 3.14-3.17 (m, 4H), 3.78-3.81 (m, 4H), 3.88 (s, 3H), 4.14 (s, 3H), 6.88-7.41 (m, 7H), 7.81 (dd, J=9.0 and 5.7 Hz. 1H).

Sources & evidence

ORD record
ord-f445ca43319743b3bd0875619ba7a554
Source dataset
uspto-grants-2013_12
Patent number
US08598173B2

Reaction notes

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