HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-Methoxyphenyl)piperazine → 1-[(6-Fluoro-3-methoxyquinoxalin-2-yl)aminocarbonyl]-4-(4-methoxyphenyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-Methoxyphenyl)piperazine | HCID 269722 | — |
| Reactant | ethyl N-(6-fluoro-3-methoxyquinoxalin-2-yl)carbamate | HCID 69243333 | — |
| Product | 1-[(6-Fluoro-3-methoxyquinoxalin-2-yl)aminocarbonyl]-4-(4-methoxyphenyl)piperazine | HCID 69244088 | 84% |
Reaction Steps
Ethyl N-(6-fluoro-3-methoxyquinoxalin-2-yl)carbamate and 1-(4-methoxyphenyl)piperazine were reacted by the same way with the example 85 to obtain the titled compound (yield, 84%). 1H NMR (200 MHz, CDCl3): δ 3.15-3.18 (m, 4H), 3.78 (s, 4H), 4.15 (s, 3H), 6.85-6.96 (m, 4H), 7.22-7.42 (m, 3H), 7.81 (dd, J=9.0 and 6.0 Hz, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08598173B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-205871cb7f05458b950d65db56234e32 |
| Source note | uspto-grants-2013_12 |