1-(2-Chlorophenyl)piperazine → HCID 69244065, compound

HRID 1907544Notes

Reaction equation

HRID 1907544 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([NH:12][C:13](=[O:17])OCC)[C:6]([O:18][CH3:19])=[N:5]2.[Cl:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[N:27]1[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1>>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([NH:12][C:13]([N:30]1[CH2:29][CH2:28][N:27]([C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=3[Cl:20])[CH2:32][CH2:31]1)=[O:17])[C:6]([O:18][CH3:19])=[N:5]2

Participants

3

Reactant 2

HCID 4156281-(2-Chlorophenyl)piperazineHCID 69243333ethyl N-(6-fluoro-3-methoxyquinoxalin-2-yl)carbamate

Product 1

HCID 69244065HCID 69244065, compoundYield 87%

Procedure

Ethyl N-(6-fluoro-3-methoxyquinoxalin-2-yl)carbamate and 1-(2-chlorophenyl)piperazine were reacted by the same way with the example 85 to obtain the titled compound (yield, 87%). 1H NMR (200 MHz, CDCl3): δ 3.13-3.16 (m, 4H), 3.78-3.81 (m, 4H), 4.15 (s, 3H), 7.02-7.06 (m, 3H), 7.23-7.42 (m, 4H), 7.82-7.83 (m, 1H).

Sources & evidence

ORD record
ord-4c3ee569ff3f4ff9b4b8749332738495
Source dataset
uspto-grants-2013_12
Patent number
US08598173B2

Reaction notes

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