1-(4-Methoxyphenyl)piperazine → 1-[(6-Chloro-3-methoxyquinoxalin-2-yl)aminocarbonyl]-4-(4-methoxyphenyl)piperazine

HRID 1907558Notes

Reaction equation

HRID 1907558 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([NH:12][C:13](=[O:17])OCC)[C:6]([O:18][CH3:19])=[N:5]2.[CH3:20][O:21][C:22]1[CH:27]=[CH:26][C:25]([N:28]2[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)=[CH:24][CH:23]=1>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([NH:12][C:13]([N:31]1[CH2:30][CH2:29][N:28]([C:25]3[CH:24]=[CH:23][C:22]([O:21][CH3:20])=[CH:27][CH:26]=3)[CH2:33][CH2:32]1)=[O:17])[C:6]([O:18][CH3:19])=[N:5]2

Participants

3

Reactant 2

HCID 2697221-(4-Methoxyphenyl)piperazineHCID 69241674ethyl N-(6-chloro-3-methoxyquinoxalin-2-yl)carbamate

Product 1

HCID 692423961-[(6-Chloro-3-methoxyquinoxalin-2-yl)aminocarbonyl]-4-(4-methoxyphenyl)piperazineYield 90%

Procedure

Ethyl N-(6-chloro-3-methoxyquinoxalin-2-yl)carbamate and 1-(4-methoxyphenyl)piperazine were reacted by the same way with the example 106 to obtain the titled compound (yield, 90%). 1H NMR (200 MHz, CDCl3): δ 3.17 (s, 4H), 3.78 (s, 7H), 4.15 (m, 3H), 6.85-6.96 (m, 4H), 7.29-7.49 (m, 2H), 7.74-7.77 (m, 2H).

Sources & evidence

ORD record
ord-b33088cfc6cc40e3abf67a18810ebcbc
Source dataset
uspto-grants-2013_12
Patent number
US08598173B2

Reaction notes

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