1-(m-Tolyl)piperazine → HCID 69244363, compound

HRID 1907562Notes

Reaction equation

HRID 1907562 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([NH:12][C:13](=[O:17])OCC)[C:6]([O:18][CH3:19])=[N:5]2.[CH3:20][C:21]1[CH:22]=[C:23]([N:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)[CH:24]=[CH:25][CH:26]=1>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([NH:12][C:13]([N:30]1[CH2:31][CH2:32][N:27]([C:23]3[CH:24]=[CH:25][CH:26]=[C:21]([CH3:20])[CH:22]=3)[CH2:28][CH2:29]1)=[O:17])[C:6]([O:18][CH3:19])=[N:5]2

Participants

3

Reactant 2

HCID 831111-(m-Tolyl)piperazineHCID 69241674ethyl N-(6-chloro-3-methoxyquinoxalin-2-yl)carbamate

Product 1

HCID 69244363HCID 69244363, compoundYield 97%

Procedure

Ethyl N-(6-chloro-3-methoxyquinoxalin-2-yl)carbamate and 1-(3-methylphenyl)piperazine were reacted by the same way with the example 106 to obtain the titled compound (yield, 97%). 1H NMR (300 MHz, CDCl3): δ 3.27-3.30 (m, 4H), 3.74-3.77 (m, 4H), 4.15 (s, 3H), 6.75-6.78 (m, 3H), 7.11-7.45 (m, 3H), 7.74-7.76 (m, 2H).

Sources & evidence

ORD record
ord-e28e379830d14506baaf2c2ad37918f9
Source dataset
uspto-grants-2013_12
Patent number
US08598173B2

Reaction notes

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