N-(2-Cyanophenyl)piperazine → HCID 69245221, compound

HRID 1907570Notes

Reaction equation

HRID 1907570 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([NH:12][C:13](=[O:17])OCC)[C:6]([O:18][CH3:19])=[N:5]2.[C:20]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[N:28]1[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1)#[N:21]>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([NH:12][C:13]([N:31]1[CH2:30][CH2:29][N:28]([C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=3[C:20]#[N:21])[CH2:33][CH2:32]1)=[O:17])[C:6]([O:18][CH3:19])=[N:5]2

Participants

3

Reactant 2

HCID 2735875N-(2-Cyanophenyl)piperazineHCID 69241674ethyl N-(6-chloro-3-methoxyquinoxalin-2-yl)carbamate

Product 1

HCID 69245221HCID 69245221, compoundYield 89%

Procedure

Ethyl N-(6-chloro-3-methoxyquinoxalin-2-yl)carbamate and 1-(2-cyanophenyl)piperazine were reacted by the same way with the example 106 to obtain the titled compound (yield, 89%). 1H NMR (300 MHz, CDCl3): δ 3.30 (s, 4H), 3.84 (s, 3H), 4.14 (s, 3H), 7.02-7.10 (m, 2H), 7.35-7.89 (m, 6H).

Sources & evidence

ORD record
ord-4e687b569d7d4b10929754aa05b5ba59
Source dataset
uspto-grants-2013_12
Patent number
US08598173B2

Reaction notes

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