Piperazin-4-ylacetophenone → HCID 69240830, compound

HRID 1907571Notes

Reaction equation

HRID 1907571 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([NH:12][C:13](=[O:17])OCC)[C:6]([O:18][CH3:19])=[N:5]2.[C:20]([C:23]1[CH:28]=[CH:27][C:26]([N:29]2[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]2)=[CH:25][CH:24]=1)(=[O:22])[CH3:21]>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([NH:12][C:13]([N:32]1[CH2:31][CH2:30][N:29]([C:26]3[CH:25]=[CH:24][C:23]([C:20](=[O:22])[CH3:21])=[CH:28][CH:27]=3)[CH2:34][CH2:33]1)=[O:17])[C:6]([O:18][CH3:19])=[N:5]2

Participants

3

Reactant 2

HCID 97269Piperazin-4-ylacetophenoneHCID 69241674ethyl N-(6-chloro-3-methoxyquinoxalin-2-yl)carbamate

Product 1

HCID 69240830HCID 69240830, compoundYield 81%

Procedure

Ethyl N-(6-chloro-3-methoxyquinoxalin-2-yl)carbamate and 1-(4-acetylphenyl)piperazine were reacted by the same way with the example 106 to obtain the titled compound (yield, 81%). 1H NMR (300 MHz, CDCl3): δ 2.54 (s, 3H), 3.50 (s, 4H), 3.79 (s, 4H), 4.15 (s, 3H), 6.89 (d, J=9.0 Hz, 2H), 7.31-7.50 (m, 2H), 7.65-7.75 (m, 2H), 7.90 (d, J=8.7 Hz, 2H).

Sources & evidence

ORD record
ord-7cba8d0ee7054df1b6314425001e762f
Source dataset
uspto-grants-2013_12
Patent number
US08598173B2

Reaction notes

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