HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(3-methoxyphenyl)piperazine → 1-[(3-Methoxy-6-methylquinoxalin-2-yl)aminocarbonyl]-4-(3-methoxyphenyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(3-methoxyphenyl)piperazine | HCID 81430 | — |
| Reactant | ethyl N-(3-methoxy-6-methylquinoxalin-2-yl)carbamate | HCID 69243736 | — |
| Product | 1-[(3-Methoxy-6-methylquinoxalin-2-yl)aminocarbonyl]-4-(3-methoxyphenyl)piperazine | HCID 69242051 | 89% |
Reaction Steps
Ethyl N-(3-methoxy-6-methylquinoxalin-2-yl)carbamate and 1-(3-methoxyphenyl)piperazine were reacted by the same way with the example 127 to obtain the titled compound (yield, 89%). 1H NMR (300 MHz, CDCl3): δ 2.49 (s, 3H), 3.19-3.32 (m, 4H), 3.61-3.90 (m, 4H), 3.79 (s, 3H), 4.17 (s, 3H), 6.44-6.58 (m, 4H), 7.00-7.65 (m, 3H), 7.72 (d, J=8.2 Hz, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08598173B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-b25434580558449094c87dce9076793b |
| Source note | uspto-grants-2013_12 |