1-(4-Methoxyphenyl)piperazine → HCID 69240755, compound

HRID 1907581Notes

Reaction equation

HRID 1907581 reaction equation
[CH3:1][O:2][C:3]1[C:4]([NH:14][C:15](=[O:19])OCC)=[N:5][C:6]2[C:11]([N:12]=1)=[CH:10][C:9]([CH3:13])=[CH:8][CH:7]=2.[CH3:20][O:21][C:22]1[CH:27]=[CH:26][C:25]([N:28]2[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)=[CH:24][CH:23]=1>>[CH3:1][O:2][C:3]1[C:4]([NH:14][C:15]([N:31]2[CH2:30][CH2:29][N:28]([C:25]3[CH:24]=[CH:23][C:22]([O:21][CH3:20])=[CH:27][CH:26]=3)[CH2:33][CH2:32]2)=[O:19])=[N:5][C:6]2[C:11]([N:12]=1)=[CH:10][C:9]([CH3:13])=[CH:8][CH:7]=2

Participants

3

Reactant 2

HCID 2697221-(4-Methoxyphenyl)piperazineHCID 69243736ethyl N-(3-methoxy-6-methylquinoxalin-2-yl)carbamate

Product 1

HCID 69240755HCID 69240755, compoundYield 96%

Procedure

Ethyl N-(3-methoxy-6-methylquinoxalin-2-yl)carbamate and 1-(4-methoxyphenyl)piperazine were reacted by the same way with the example 127 to obtain the titled compound (yield, 96%). 1H NMR (200 MHz, CDCl3): δ 2.50 (s, 3H), 3.15-3.17 (m, 4H), 3.68-3.78 (m, 4H), 3.78 (s, 3H), 4.14 (s, 3H), 6.84-7.75 (m, 8H).

Sources & evidence

ORD record
ord-b242ee15c01c4206b600b2f1d8a9f8f0
Source dataset
uspto-grants-2013_12
Patent number
US08598173B2

Reaction notes

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