HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(3,4,5-Trimethoxyphenyl)piperazine → 1-[(3-Methoxy-6-methylquinoxalin-2-yl)aminocarbonyl]-4-(3,4,5-trimethoxyphenyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(3,4,5-Trimethoxyphenyl)piperazine | HCID 3838765 | — |
| Reactant | ethyl N-(3-methoxy-6-methylquinoxalin-2-yl)carbamate | HCID 69243736 | — |
| Product | 1-[(3-Methoxy-6-methylquinoxalin-2-yl)aminocarbonyl]-4-(3,4,5-trimethoxyphenyl)piperazine | HCID 69243895 | 91% |
Reaction Steps
Ethyl N-(3-methoxy-6-methylquinoxalin-2-yl)carbamate and 1-(3,4,5-trimethoxyphenyl)piperazine were reacted by the same way with the example 127 to obtain the titled compound (yield, 91%). 1H NMR (300 MHz, CDCl3): δ 2.49 (s, 3H), 3.16-3.23 (m, 4H), 3.71-3.95 (m, 4H), 3.80 (s, 3H), 3.86 (s, 6H), 4.13 (s, 3H), 6.19 (s, 2H), 7.08-7.62 (m, 3H), 7.72 (d, J=8.6 Hz, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08598173B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-7005192b98f7416bab81c9fbaa434136 |
| Source note | uspto-grants-2013_12 |