HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(3-methoxyphenyl)piperazine → 1-[(3,6-Dimethoxyquinoxalin-2-yl)aminocarbonyl]-4-(3-methoxyphenyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(3-methoxyphenyl)piperazine | HCID 81430 | — |
| Reactant | ethyl N-(3,6-dimethoxyquinoxalin-2-yl)carbamate | HCID 69244324 | — |
| Product | 1-[(3,6-Dimethoxyquinoxalin-2-yl)aminocarbonyl]-4-(3-methoxyphenyl)piperazine | HCID 69244415 | 90% |
Reaction Steps
Ethyl N-(3,6-dimethoxyquinoxalin-2-yl)carbamate and 1-(3-methoxyphenyl)piperazine were reacted by the same way with the example 148 to obtain the titled compound (yield, 90%). H NMR (300 MHz, CDCl3): δ 3.27 (s, 4H), 3.75 (s, 4H), 3.79 (s, 3H), 3.89 (s, 3H), 4.12 (s, 3H), 6.44-6.57 (m, 3H), 7.14-7.22 (m, 4H), 7.72-7.75 (m, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08598173B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-6a6774c6376440088b4dd48a2668f1d2 |
| Source note | uspto-grants-2013_12 |