1-(2,6-Xylyl)piperazine → HCID 69240983, compound

HRID 1907608Notes

Reaction equation

HRID 1907608 reaction equation
[CH3:1][O:2][C:3]1[C:4]([NH:15][C:16](=[O:20])OCC)=[N:5][C:6]2[C:11]([N:12]=1)=[CH:10][C:9]([O:13][CH3:14])=[CH:8][CH:7]=2.[CH3:21][C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([CH3:28])[C:23]=1[N:29]1[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]1>>[CH3:1][O:2][C:3]1[C:4]([NH:15][C:16]([N:32]2[CH2:33][CH2:34][N:29]([C:23]3[C:24]([CH3:28])=[CH:25][CH:26]=[CH:27][C:22]=3[CH3:21])[CH2:30][CH2:31]2)=[O:20])=[N:5][C:6]2[C:11]([N:12]=1)=[CH:10][C:9]([O:13][CH3:14])=[CH:8][CH:7]=2

Participants

3

Reactant 2

HCID 705381-(2,6-Xylyl)piperazineHCID 69244324ethyl N-(3,6-dimethoxyquinoxalin-2-yl)carbamate

Product 1

HCID 69240983HCID 69240983, compoundYield 91%

Procedure

Ethyl N-(3,6-dimethoxyquinoxalin-2-yl)carbamate and 1-(2,6-dimethylphenyl)piperazine were reacted by the same way with the example 148 to obtain the titled compound (yield, 91%). 1H NMR (300 MHz, CDCl3): δ 2.36 (s, 6H), 3.17-3.21 (m, 4H), 3.68-3.71 (m, 4H), 3.91 (s, 3H), 4.14 (s, 3H), 6.95-7.03 (m, 3H), 7.14-7.21 (m, 3H), 7.77-7.80 (m, 1H).

Sources & evidence

ORD record
ord-3d90e3ee3f414bdea81c32a4104d1cb6
Source dataset
uspto-grants-2013_12
Patent number
US08598173B2

Reaction notes

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