HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(m-Tolyl)piperazine → 1-[(6,7-Dichloro-2-methoxyquinoxalin-3-yl)aminocarbonyl]-4-(3-methylphenyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(m-Tolyl)piperazine | HCID 83111 | — |
| Reactant | Ethyl N-(6,7-dichloro-2-methoxyquinoxalin-3-yl)carbamate | HCID 69243293 | — |
| Product | 1-[(6,7-Dichloro-2-methoxyquinoxalin-3-yl)aminocarbonyl]-4-(3-methylphenyl)piperazine | HCID 69244383 | 71% |
Reaction Steps
Ethyl N-(6,7-dichloro-2-methoxyquinoxalin-3-yl)carbamate and 1-(3-methyl phenyl)piperazine were reacted by the same way with the example 176 to obtain the titled compound (yield, 71%). 1H NMR (300 MHz, CDCl3) δ 2.34 (s, 3H), 3.18-3.21 (m, 4H), 3.75-3.79 (m, 4H), 4.14 (s, 3H), 6.75-6.78 (m, 4H), 7.32 (br s, 1H), 7.85 (s, 1H), 7.92 (s, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08598173B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-3a68064932094622bfaec70d44ceecca |
| Source note | uspto-grants-2013_12 |