反应详情

温度

142.5 °C

6.75 g of diethyl (3,5-dichloro-2-pyridyl)malonate and 20 ml of dimethyl sulfoxide were mixed. To the mixture was added 1.57 g of sodium chloride and 0.79 g of water. The mixture was stirred for about 40 minutes at an inner temperature of 135 to 150° C. The mixture was allowed to cool to room temperature, then, water was added to the reaction mixture, and extracted with ethyl acetate. The organic layer was washed with saturated brine twice, and dried over anhydrous magnesium sulfate, then, concentrated under reduced pressure, to obtain 4.76 g of ethyl (3,5-dichloro-2-pyridyl)acetate.

1. temperatureto cool to room temperature
2. extractionextracted with ethyl acetate
3. washThe organic layer was washed with saturated brine twice
4. dry with materialdried over anhydrous magnesium sulfate
5. concentrationconcentrated under reduced pressure