HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1907692Generated: October 30, 2026
(R)-Methyl 4-((3-(dimethylamino)pyrrolidin-1-yl)methyl)benzoate → (R)-4-((3-(Dimethylamino)pyrrolidin-1-yl)methyl)benzoic acid
https://huagongshe.com/reaction/1907692
Participants
| Role | Name | HCID | Charge |
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| Reactant | (R)-Methyl 4-((3-(dimethylamino)pyrrolidin-1-yl)methyl)benzoate | HCID 59737485 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | (R)-4-((3-(Dimethylamino)pyrrolidin-1-yl)methyl)benzoic acid | HCID 59737509 | 124.6% |
Reaction Steps
Compound 6 (0.55 g, 2.1 mmol) was heated to 110° C. in 2N aqueous hydrochloric acid (7 mL) for 18 h then cooled to −78° C. and lyophilized to give compound 7 as a grey solid (0.65 g, 97% yield). LRMS: 248.2 (calc), 249.0 (obs).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08598168B2 |
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| Source dataset | uspto-grants-2013_12 |
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| ORD ID | ord-bf332639587849eebc950eb7b01f5929 |
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| Source note | uspto-grants-2013_12 |
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