Acrylic Acid → HCID 59737294, compound

HRID 1907713Notes

Reaction equation

HRID 1907713 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)=[N:6][CH:7]=1.[C:14]([O:18]C(C)(C)C)(=[O:17])[CH:15]=[CH2:16].C(O)(=O)C=C>>[O:11]1[CH2:12][CH2:13][N:8]([C:5]2[N:6]=[CH:7][C:2](/[CH:16]=[CH:15]/[C:14]([OH:18])=[O:17])=[CH:3][CH:4]=2)[CH2:9][CH2:10]1

Participants

4

Reactant 3

HCID 6581Acrylic AcidHCID 15458tert-Butyl acrylateHCID 109667244-(5-bromopyridin-2-yl)morpholine

Product 1

HCID 59737294HCID 59737294, compoundYield 41%

Procedure

Following the same procedure as described in Example 2, step 2 (scheme 2), but substituting compound 37 for compound 163, and compound 38 for acrylic acid, title compound 164 was obtained (41% yield).

Sources & evidence

ORD record
ord-efadfe319a6c4caf97cbac0d1921608f
Source dataset
uspto-grants-2013_12
Patent number
US08598168B2

Reaction notes

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