Potassium Hydroxide → 7-(3-(Phenyl)phenylcarbamoyl)heptanoic acid

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Reaction Steps

A solution of compound 182 (0.212 g, 0.62 mmol) in THF (10 mL) was treated with potassium hydroxide (5 mL of a 3.5% aqueous solution) and stirred at room temperature for 72 h then concentrated, diluted with diethyl ether and acidified with citric acid. The acidic mixture was extracted with AcOEt, washed with H2O, dried over MgSO4, filtered, and concentrated to give title compound 183 (0.182 g, 90% yield).

Provenance & Evidence