HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1907718Generated: October 30, 2026
5-Formyl-2-thiopheneboronic acid → 5-Hydroxymethylthiophene-2-boronic acid
https://huagongshe.com/reaction/1907718
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 5-Formyl-2-thiopheneboronic acid | HCID 2773430 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 5-Hydroxymethylthiophene-2-boronic acid | HCID 4374265 | — |
Reaction Steps
A suspension of 5-formylthiophen-2-ylboronic acid 185 (1.096 g, 7.03 mmol) in isopropanol (10 mL), stirred at 0° C., was treated with solid sodium borohydride (0.336 g, 8.88 mmol) added portion-wise at 0° C. then stirred for 75 min. The reaction was quenched with acetone and concentrated to give compound 186 (used directly in Step 2).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08598168B2 |
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| Source dataset | uspto-grants-2013_12 |
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| ORD ID | ord-da55a17eb1c64fc9b09125e1ca4e53ac |
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| Source note | uspto-grants-2013_12 |
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