2-(Dimethylamino)ethanol → HCID 59737376, compound

Participants

Reaction Steps

A solution of carbonyl diimadzole (CDI) (609 mg, 3.76 mmol) in pyridine (5 mL) was treated with neat dimethylaminoethanol (400 μL, 3.98 mmol) and the mixture was stirred for 15 h at room temperature. Methyl 4-(aminomethyl)benzoate hydrochloride (217) (794 mg, 3.82 mmol) was then added and the reaction mixture was stirred for further 7 h, diluted with DCM, washed with saturated NaHCO3, dried over MgSO4, filtered and concentrated to produce title compound 218 as a white solid (1.16 g, >100% yield, crude, used without additional purification).

Provenance & Evidence