4-Formylbenzoic acid → HCID 15296710, compound

Participants

Reaction Steps

A solution of 4-formylbenzoic acid (223) (306 mg, 2.04 mmol) and tert-butyl 2-(diethoxyphosphoryl)acetate (0.8 mL, 3.23 mmol) in ethyleneglycol dimethylether (15 mL) was stirred at 0° C. then treated with sodium hydride (60% in oil, 312 mg, 7.8 mmol), further stirred for 1 h then at room temperature for 3 h. The reaction mixture was diluted with acetone, stirred 10 min then treated with 5% aqueous KHSO4, extracted with DCM. The extract was dried over MgSO4, filtered and concentrated to provide title compound 224 as a white solid (811.5 mg, >100% yield, crude, used in the next step without additional purification).

Provenance & Evidence