HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → (E)-N-(2-Amino-5-(thiophen-2-yl)phenyl)-4-(3-(hydroxyamino)-3-oxoprop-1-enyl)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | (R)-4-((3-(Dimethylamino)pyrrolidin-1-yl)methyl)benzoic acid | HCID 59737509 | — |
| Reactant | (E)-3-(4-(2-Amino-5-(thiophen-2-yl)phenylcarbamoyl)phenyl)acrylic acid trifluoroacetate | HCID 69101378 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (E)-N-(2-Amino-5-(thiophen-2-yl)phenyl)-4-(3-(hydroxyamino)-3-oxoprop-1-enyl)benzamide | HCID 59737322 | 79% |
Reaction Steps
Following the same procedure as described in Example 1, step 6 (scheme 1), but substituting compound 4 for N-hydroxylamine hydrochloride salt and compound 7 for compound 226, the title compound 227 was obtained as a yellowish solid in 79% yield [purified by flash chromatography (eluent: 5% to 66% MeOH in DCM)].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08598168B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-b7bf7214934c4f8d852c225abd04e7b9 |
| Source note | uspto-grants-2013_12 |