Thioglycolic Acid → HCID 59737563, compound

Participants

Reaction Steps

To a solution of 247 (0.65 g, 0.86 mmol) in DMF (5 mL) was added mercaptoacetic acid (0.103 g, 1.12 mmol) followed by solid lithium hydroxide (0.108 g, 2.58 mmol). The reaction mixture was allowed to stir at room temperature for 18 h and then at 70° C. for 4 h. The reaction mixture was concentrated, diluted with AcOEt and extracted with H2O, saturated NaHCO3, brine, dried over MgSO4, filtered and concentrated to give a yellow oil which was purified by flash chromatography (eluents: 100% EtOAc then 2.5% MeOH/1% Et3N/96.5% EtOAc and finally, 5% MeOH/1% Et3N/94% EtOAc) to provide title compound 248 (0.333 g, 68% yield).

Provenance & Evidence