Hydrochloric Acid → HCID 86620426, compound

Participants

Reaction Steps

To a 1M solution of lithium bis(trimethylsilyl)amide in THF (0.0.76 mL, 0.76 mmol) at 0° C. was added compound 251 (0.10 g, 0.24 mmol). The reaction mixture was allowed to warm to room temperature, stirred for 18 h, cooled to 0° C., treated with 1N HCl (15 mL), stirred for 30 min and concentrated. The residue was diluted with AcOEt and extracted with H2O. The aqueous phase was collected, neutralized with 1N NaOH, extracted with AcOEt, dried over MgSO4, filtered and concentrated. The resulting brown solid was triturated with diethyl ether to give intermediate 252 (50 mg, 48% yield).

Provenance & Evidence