Sodium borohydride → HCID 59737383, compound

Participants

Reaction Steps

To a stirring solution of amine 260 (0.11 g, 6.31 mmol) in DCM (9 mL) and cerium (III) chloride heptahydrate (0.37 g, 0.93 mmol) in MeOH (6 mL) at −78° C. was added sodium borohydride (60 mg, 0.93 mmol) in one portion. The reaction mixture was allowed to warm to room temperature and stirred for 15 min then concentrated. Purifications by flash chromatography (eluent: 5% MeOH in DCM) followed by chromatotron (same eluent) provided the title compounds 261 (15 mg, 14% yield) and 262 (15 mg, 16% yield).

Provenance & Evidence