HRID1907743

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID59737247

未命名化合物

结构：CC(C)(C)OC(=O)Nc1ccc(-c2ccc(Cl)s2)cc1N

HCID59737400

未命名化合物

HCID59737509

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)Nc1ccc(-c2cccs2)cc1NC(=O)c1ccc(N2CCC(N3CCOCC3)C2)cc1

HCID86620428

未命名化合物

收率 40%

PROCEDURE

实验过程

Following the same procedure as described in Example 1, step 6 (scheme 1), but substituting compound 4 for compound 168 and compound 7 for compound 269, title compound 270 was obtained in 40% yield.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-bf86a3fa52994c008434f1b070797790
来源数据集: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08598168B2
来源说明: uspto-grants-2013_12

反应 SMILES

[NH2:1][C:2]1[CH:7]=[C:6]([C:8]2[S:9][C:10](Cl)=[CH:11][CH:12]=2)[CH:5]=[CH:4][C:3]=1[NH:14][C:15](=[O:21])[O:16][C:17]([CH3:20])([CH3:19])[CH3:18].CN(C)[C@@H]1CCN(CC2C=CC(C(O)=O)=CC=2)C1.[O:40]1[CH2:45][CH2:44][N:43]([CH:46]2[CH2:50][CH2:49][N:48]([C:51]3[CH:59]=[CH:58][C:54]([C:55](O)=[O:56])=[CH:53][CH:52]=3)[CH2:47]2)[CH2:42][CH2:41]1>>[O:40]1[CH2:45][CH2:44][N:43]([CH:46]2[CH2:50][CH2:49][N:48]([C:51]3[CH:59]=[CH:58][C:54]([C:55]([NH:1][C:2]4[CH:7]=[C:6]([C:8]5[S:9][CH:10]=[CH:11][CH:12]=5)[CH:5]=[CH:4][C:3]=4[NH:14][C:15](=[O:21])[O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:56])=[CH:53][CH:52]=3)[CH2:47]2)[CH2:42][CH2:41]1