Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate → HCID 59737479, compound

Participants

Reaction Steps

The acid 325 (3.23 g, 7.03 mmol) and BOP (4.66 g, 10.55 mmol) were added to a solution of 322 (1.2 g, 7.03 mmol) (Compound 322 was synthesized following general procedures B and C starting from compound 2 and phenylboronic acid) in pyridine (40 mL). The reaction mixture was stirred at room temperature for 24 h, concentrated under reduced pressure, diluted with DCM, washed with water, NaHCO3 and brine. The residue was purified by flash chromatography (2-4% MeOH in DCM) to give the title compound 326 (1.74 g, 43%) as a brown solid.

Provenance & Evidence