Trifluoroacetic acid → (S)-N-(4-Aminobiphenyl-3-yl)-4-(3-aminopyrrolidin-1-yl)benzamide

Participants

Reaction Steps

TFA (1 mL) was added to a solution of 326 (370 mg, 0.65 mmol) in DCM (1 mL). The reaction mixture was stirred at room temperature for 24 h, concentrated and the residue was partitioned between EtOAc and NaHCO3. The aqueous layer was extracted with fresh EtOAc and the comb organic layers were washed with brine, dried over MgSO4 and concentrated. The residue was purified using the Biotage system, (cartridge Biotage Si 25+M), eluent MeOH/DCM (10% to 40%) to afford the title compound 327 (161 mg, 67% yield).

Provenance & Evidence