Tetrahydrofuran → HCID 86620430, compound

Participants

Reaction Steps

Dibutyltin dichloride (28 mg, 0.09 mmol) and phenylsilane (365 mg, 3.37 mmol) were added to a suspension of 457 (1.05 g, 3.07 mmol), in THF (6.1 mL). The reaction mixture was stirred for 48 h at room temperature, diluted with AcOEt, washed with water and brine, dried over MgSO4, filtered and concentrated. The residue was purified by flash chromatography to afford the title compound 458 (647 mg, 61% yield) as a white solid.

Provenance & Evidence