Hydrochloric Acid → HCID 67419385, compound

Participants

Reaction Steps

In a 100-mL single-neck round-bottomed flask equipped with a magnetic stirrer 10d (300 mg, 0.530 mmol) was dissolved in methanol (3.0 mL). To this solution 4M hydrogen chloride in dioxane (3 mL) was added, and this mixture was stirred at room temperature for 2 h under nitrogen. The reaction mixture was then concentrated under reduced pressure, and the resulting residue was partitioned between ethyl acetate (20 mL) and water (20 mL). The mixture was neutralized with saturated potassium carbonate to pH 6.5 (pH meter). The aqueous layer was separated and extracted with ethyl acetate (2×50 mL), The combined organic layers were washed with brine (100 mL) and dried over sodium sulfate. The drying agent was removed by filtration and the filtrate was evaporated under reduced pressure. The resulting residue was purified on a silica gel column eluting the desired product with 16% methanol in methylene chloride to afford a 65% yield (161 mg) of 10e as a off-white solid: mp 140-141° C.; 1H NMR (500 MHz, DMSO d6) δ 12.79 (s, 1H), 10.37 (s, 1H), 9.23 (s, 1H), 8.92 (s, 1H), 8.48 (d, 1H, J=7.5 Hz), 7.75 (m, 1H), 7.40 (m, 1H), 6.91 (s, 1H), 4.19 (d, 1H, J=9.5 Hz), 4.03 (d, 1H, J=13.0 Hz), 2.99-2.82 (m, 4H), 1.93 (m, 1H), 1.75 (m, 1H), 1.58 (m, 1H), 1.42 (s, 9H), 1.29 (m, 1H); MS (APCI−) m/z 464.6 (M−H).

Provenance & Evidence