Ammonia → HCID 58137373, compound

HRID 1907821Notes

Reaction equation

HRID 1907821 reaction equation
CS(O[CH2:6][C:7]1[N:8]=[N:9][C:10]([O:16][CH2:17][CH3:18])=[C:11]([O:13][CH2:14][CH3:15])[CH:12]=1)(=O)=O.[NH3:19]>CO>[CH2:14]([O:13][C:11]1[CH:12]=[C:7]([CH2:6][NH2:19])[N:8]=[N:9][C:10]=1[O:16][CH2:17][CH3:18])[CH3:15]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 58137372HCID 58137372, compound

Product 1

HCID 58137373HCID 58137373, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

5,6-Diethoxypyridazin-3-ylmethyl methanesulfonate (620 mg) was dissolved in methanol (10 ml) and added dropwise while cooling with ice to an ammonia solution (16 ml; 7N in methanol). After being stirred for 6 h and left to stand overnight, the solvent was drawn off and the residue was purified by means of preparative HPLC. The product-containing fractions were combined, freed of the acetonitrile and freeze-dried. 305 mg of the desired product were obtained.

Workup

  1. additionadded dropwise
  2. waitleft
  3. waitto stand overnight
  4. customthe residue was purified by means of preparative HPLC
  5. customfreeze-dried

Sources & evidence

ORD record
ord-b1e2166272c448f6b00c25273c91db81
Source dataset
uspto-grants-2013_12
Patent number
US08598177B2

Reaction notes

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