Nitric Acid → 2-Bromo-5-fluoro-4-nitropyridine 1-oxide

HRID 1907875Notes

Reaction equation

[Br:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][N+:3]=1[O-:9].S(=O)(=O)(O)O.[N+:15]([O-])([OH:17])=[O:16]>>[Br:1][C:2]1[CH:7]=[C:6]([N+:15]([O-:17])=[O:16])[C:5]([F:8])=[CH:4][N+:3]=1[O-:9]

Participants

Reactant 3

HCID 944Nitric Acid

HCID 1118Sulfuric Acid

HCID 552510482-Bromo-5-fluoropyridine 1-oxide

Product 1

HCID 707008042-Bromo-5-fluoro-4-nitropyridine 1-oxide

Procedure

Prepared analogously to example 83b from 2-bromo-5-fluoropyridine 1-oxide, conc. sulphuric acid and conc. nitric acid

Sources & evidence

ORD record: ord-f7c09b922cec4ea0a86f5970d5ab7de0
Source dataset: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08598190B2

Reaction notes

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