HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-Amino-5-nitropyridine-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Methyl 4-amino-5-nitropyridine-2-carboxylate | HCID 46835478 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-Amino-5-nitropyridine-2-carboxylic acid | HCID 13040402 | — |
Reaction Steps
A mixture of methyl-4-amino-5-nitropicolinate (200 mg, 1.01 mmol) and NaOH (aq, 1M, 2.0 mL, 2.0 mmol) in methanol was stirred at ambient temperature for 10 min. The mixture was acidified by addition of HCl (aq, 1M, 2.1 mL, 2.1 mmol) and concentrated i. vac. and the aqueous residing mixture filtered. The solid was washed with water and dried i. vac.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08598190B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-55befc6ebcd748beac40249d533ed487 |
| Source note | uspto-grants-2013_12 |