Sulfuric Acid → Methyl 4-amino-5-nitropyridine-2-carboxylate

HRID 1907884Notes

Reaction equation

[CH3:1][O:2][C:3](=[O:11])[C:4]1[CH:9]=[C:8]([NH2:10])[CH:7]=[CH:6][N:5]=1.S(=O)(=O)(O)O.[N+:17]([O-])([O-:19])=[O:18].[K+]>>[CH3:1][O:2][C:3](=[O:11])[C:4]1[CH:9]=[C:8]([NH2:10])[C:7]([N+:17]([O-:19])=[O:18])=[CH:6][N:5]=1

Participants

Reactant 3

HCID 1118Sulfuric Acid

HCID 24434Potassium Nitrate

HCID 3759117Methyl 4-aminopyridine-2-carboxylate

Product 1

HCID 46835478Methyl 4-amino-5-nitropyridine-2-carboxylate

Procedure

Prepared analogously to example 83b from methyl-4-aminopicolinate, conc. sulphuric acid and potassium nitrate.

Sources & evidence

ORD record: ord-495cdbb1e7514474b515bc65b3d40799
Source dataset: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08598190B2

Reaction notes

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