HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → BI 207127
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | MeOH tetrahydrofuran | HCID 21899815 | — |
| Reactant | HCID 86665161 | HCID 86665161 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | BI 207127 | HCID 56948249 | — |
Reaction Steps
In this process, hydrolysis of (E)-butyl 3-(2-(1-(2-(5-bromopyrimidin-2-yl)-3-cyclopentyl-1-methyl-1H-indole-6-carboxamido)cyclobutyl)-1-methyl-1H-benzo[d]imidazol-6-yl)acrylate was carried out in mixture of THF/MeOH and aq NaOH. Controlled acidification of the corresponding sodium salt with acetic acid is very critical to obtain easy-filtering crystalline product in high yield and purity.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08598183B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-411256c57407476b9048850da7da7fc3 |
| Source note | uspto-grants-2013_12 |