HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenol → Diphenyl Ether
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenol | HCID 996 | — |
| Reactant | Chloroacetonitrile | HCID 7856 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Fluorobenzoyl chloride | HCID 67879 | — |
| Reactant | 13450-05-0 | HCID 3461945 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | Diphenyl Ether | HCID 7583 | — |
Reaction Steps
Compound 239 was prepared from 9b-(4-hydroxyphenyl)-1,2,3,9b-tetrahydroimidazo[2,1-a]isoindol-5-one using Method L. The tetrahydroimidazoisoindolone was bis-acylated with 4-fluorobenzoyl chloride according to Method H and the resulting phenolic ester function was converted to a phenol by basic hydrolysis. The product was then treated with chloroacetonitrile and K2CO3 in acetone and heated to reflux for 30 h to yield phenyl ether compound 239.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08598193B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-ca046bd3064643f99cfd1b5331b2c8d1 |
| Source note | uspto-grants-2013_12 |