HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diphenylsilane → 4-(4-Bromo-3-fluorobenzyl)morpholine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diphenylsilane | HCID 69888 | — |
| Reactant | (4-Bromo-3-fluorophenyl)(morpholin-4-yl)methanone | HCID 48474115 | — |
| Catalyst | Carbonyltris(triphenylphosphine)rhodium(I)hydride | HCID 53249357 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-(4-Bromo-3-fluorobenzyl)morpholine | HCID 53417818 | — |
Reaction Steps
A 250 ml flask was charged with (4-bromo-3-fluorophenyl)(morpholino)methanone (4.569 g, 15.86 mmol) and dissolved in 16 mL of THF. Diphenylsilane (6.2 ml, 33.4 mmol) was added followed by carbonyltris(triphenylphosphine)rhodium(I)hydride (100 mg, 0.109 mmol) and the reaction stirred at room temperature for 20 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08598169B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-7f048c54528c4de8b280552f6360c4a3 |
| Source note | uspto-grants-2013_12 |