1,4-Dioxane → HCID 58551180, compound

Participants

Reaction Steps

A solution of tert-butyl 7′-cyanospiro[piperidine-4,4′-pyrrolo[2,1-c][1,4]benzoxazine]-1-carboxylate (1.1 g, 3.1 mmol) in HCl in dioxane (3.1 mL of 4.0 M, 12 mmol) was stirred at room temperature for 1 hour. The reaction mixture was evaporated to dryness to yield spiro[benzo[b]pyrrolo[1,2-d][1,4]oxazine-4,4′-piperidine]-7-carbonitrile (880 mg, 94%). ESI-MS m/z calc. 265.3. found 266.1 (M+1)+. Retention time: 0.92 minutes (3 min run).

Provenance & Evidence