Triacetoxyperiodinane → Tert-butyl 3-acetyl-4-oxospiro[chroman-2,4'-piperidine]-1'-carboxylate

Participants

Reaction Conditions

Reaction Steps

A mixture of tert-butyl 3-(1-hydroxyethyl)-4-oxospiro[chroman-2,4′-piperidine]-1′-carboxylate (600 mg, 1.66 mmol) and Dess-Martin periodinane (8.3 mL of 0.30 M, 2.5 mmol) was stirred at 25° C. for 5 h. The reaction mixture was diluted with dichloromethane, washed with saturated aqueous NaHCO3 (2×), 5% Na2S2O3 (2×), brine, dried over MgSO4, filtered and concentrated to dryness. Purification by silica gel chromatography provided tert-butyl 3-acetyl-4-oxospiro[chroman-2,4′-piperidine]-1′-carboxylate (435 mg, 73%). ESI-MS m/z calc. 359.2. found 360.4 (M+1)+; Retention time: 2.84 minutes (4 min run). 1H NMR (400 MHz, CDCl3) δ 7.86 (dd, J=7.8, 1.5 Hz, 1H), 7.60-7.52 (m, 1H), 7.07-7.01 (m, 2H), 4.10-3.79 (m, 2H), 3.76 (s, 1H), 3.29-3.03 (m, 2H), 2.27 (s, 3H), 2.10-1.85 (m, 3H), 1.68-1.58 (m, 1H), 1.47 (s, 9H).

Provenance & Evidence