Hydrochloric Acid → (S)-2-[4-(2,5-difluoro-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-4-methyl-pentanoic acid

Participants

Reaction Conditions

Reaction Steps

A mixture of (S)-2-[4-(2,5-difluoro-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-4-methyl-pentanoic acid methyl ester (0.38 g, 1.11 mmol) in tetrahydrofuran (8.4 mL) and water (2.8 mL) was treated with lithium hydroxide monohydrate (56 mg, 1.34 mmol). The reaction was stirred at 25° C. overnight. At this time, the reaction was diluted with water (100 mL), acidified with a 2N aqueous hydrochloric acid solution and then extracted with 10% methanol/dichloromethane (3×75 mL). The combined organics were dried over sodium sulfate, filtered and concentrated in vacuo to afford (S)-2-[4-(2,5-difluoro-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-4-methyl-pentanoic acid (0.36 g, 99%) as a light yellow foam: HR-ES-MS m/z calculated for C16H17NO4F2 [M+Na]+ 348.1018, observed 348.1018; 1H NMR (400 MHz, DMSO-d6) δ ppm 0.87 (d, J=6.5 Hz, 3H), 0.93 (d, J=6.5 Hz, 3H), 1.38-1.52 (m, 1H), 1.62 (ddd, J=14.0, 9.7, 4.4 Hz, 1H), 1.77-1.84 (m, 1H), 4.17 (d, J=18.2 Hz, 1H), 4.28 (d, J=18.2 Hz, 1H), 4.63 (dd, J=11.6, 4.4 Hz, 1H), 5.05 (s, 1H), 7.21-7.33 (m, 1H), 7.46-7.62 (m, 2H), 12.83 (br. s., 1H).

Provenance & Evidence