反应详情

温度

80 °C

Methyl 3-fluoro-4-isopropoxybenzoate (from step 1), 1,4-dioxane (31 mL), and NaOH (31 mL of 1.0 M, 31 mmol) were combined and the mixture was heated at 80° C. for 20 min. The solvent was evaporated under reduced pressure. The crude mixture was dissolved in water and was washed with EtOAc (3×). The combined organics were discarded. The aqueous layer was acidified and was extracted with EtOAc (3×). The organic layer was dried over sodium sulfate, filtered and the concentrated under reduced pressure to yield 3-fluoro-4-isopropoxy-benzoic acid (1.25 g, 72%) as a white solid. ESI-MS m/z calc 198.1. found 199.3 (M+1)+. Retention time: 1.34 minutes (3 min run).

1. customThe solvent was evaporated under reduced pressure
2. dissolutionThe crude mixture was dissolved in water
3. washwas washed with EtOAc (3×)
4. extractionwas extracted with EtOAc (3×)
5. dry with materialThe organic layer was dried over sodium sulfate
6. filtrationfiltered
7. concentrationthe concentrated under reduced pressure