Potassium Phosphate, Tribasic → HCID 44204534, compound

Participants

Reaction Conditions

Reaction Steps

4-Chloro-6-(4-trifluoromethoxy-phenyl)-pyrimidine. To a suspension of 4,6-dichloropyrimidine (2.18 g, 14.7 mmol) and 4-trifluoromethoxyphenyl boronic acid (3.32 g, 16.1 mmol) in DME (72 mL) and water (18 mL) were added K3PO4 (6.24 g, 29.4 mmol) and Pd(PPh3)4 (0.51 g, 0.44 mmol). The reaction mixture was heated at 85° C. under N2 for 16 h. The reaction mixture was cooled to rt and the organic layer separated, dried (MgSO4), and concentrated. The residue was purified (FCC) to give the title compound as a yellow solid (2.20 g, 54%).

Provenance & Evidence